Mitarbeitende

PD Dr. med. Bettina Wölnerhanssen

Portrait PD Dr. med. Bettina Wölnerhanssen

seit 2019        
Leiterin St. Clara Forschung AG

2018-2019     
Stv. Leiterin St. Clara Forschung AG

2018
Habilitation, Experimentelle Medizin, Universität Basel

2016-2018     
Senior Scientist, klinische Forschungsabteilung St. Claraspital Basel

2011-2015                             
Research Fellow, klinische Forschung Department für Biomedizin, Gastroenterologie, Universitätsspital Basel 

2010                          
Facharztexamen FMH-Chirurgie

2002-2010                 
Assistenzärztin Chirurgie: St. Claraspital Basel, Kinderspital Zürich, Universitätsspital Basel, Traumatologie Helsingborg (Schweden), Kantonsspital Bruderholz

2002               
Forschungsaufenthalt (6 Monate) University of Pennsylvania/Children’s Hospital of Philadelphia, USA 

2002 
Promotion “Whiplash injury: prospective clinical and MR study”, Universität Basel

1995-2001                             
Staatsexamen Humanmedizin Universität Basel 

2000 & 2001                         
US Staatsexamen (USMLE Step 1+ 2)

 

Forschungsschwerpunkte:

·       Übergewicht/Diabetes

·       Metabole (Bariatrische) Chirurgie

·       Sättigungsregulation und Energiehaushalt

·       Gut-Brain-Axis

·       Kohlenhydratstoffwechsel, Zucker und Zuckeralternativen

Original articles

  • Meyer-Gerspach AC, Wingrove JO, Beglinger C, Rehfeld JF, Le Roux CW, Peterli R, Dupont P, O'Daly O, Van Oudenhove L, Wölnerhanssen BK. Erythritol and xylitol differentially impact brain networks involved in appetite regulation in healthy volunteers. Nutr Neurosci. 2021 Aug 18;1-15. doi: Online ahead of print.
     
  • Kraljević M, Cordasco V, Schneider R, Peters T, Slawik M, Wölnerhanssen B, Peterli R. Correction to: Long-Term Effects of Laparoscopic Sleeve Gastrectomy: What Are the Results beyond 10 Years? Obes Surg. 2021 Aug;31(8):3434-3435. doi: Erratum for: Obes Surg. 2021 Aug;31(8):3427-3433.
     
  • Schneider R, Schulenburg M, Kraljević M, Klasen JM, Peters T, Wölnerhanssen B, Peterli R. Does the non-absorbable suture closure of the jejunal mesenteric defect reduce the incidence and severity of internal hernias after laparoscopic Roux-en-Y gastric bypass? Langenbecks Arch Surg. 2021 May 22. doi: Epub ahead of print.
     
  • Kraljević M, Schneider R, Wölnerhanssen B, Bueter M, Delko T, Peterli R. Different limb lengths in gastric bypass surgery: study protocol for a Swiss multicenter randomized controlled trial (SLIM). Trials. 2021 May 19;22(1):352. doi:
     
  • Stillhard B, Ngo BTT, Peterli R, Peters T, Schneider R, Kraljević M, Slawik M, Wölnerhanssen B. Preoperative Cardiac Diagnostics in Bariatric Patients with Diabetes and Perioperative Morbidity: Results of a Cohort of 258 Patients. Obes Surg. 2021 Mar. DOI: 10.1007/s11695-021-05300-5
     
  • Wölnerhanssen BK, Drewe J, Verbeure W, le Roux CW, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Meyer-Gerspach AC. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes Obes Metab. 2021 Feb. DOI: 10.1111/dom.14342
     
  • Bühler J, Rast S, Beglinger C, Peterli R, Peters T, Gebhart M, °Meyer-Gerspach AC, °Wölnerhanssen BK. Long-Term Effects of Laparoscopic Sleeve Gastrectomy and Roux-Y-Gastric Bypass on Body Composition and Bone Mass Density. Obesity Facts. 2021 Mar. 14(1):131-140. DOI: 10.1159/000512450 °authors contributed equally to the manuscript
     
  • Meyer-Gerspach AC, Drewe J, Verbeure W, Roux CWL, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Wölnerhanssen BK. Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study. Nutrients. 2021 Jan. 8;13(1):174. https://doi.org/10.3390/nu1301017
     
  • Wölnerhanssen BK, Peterli R, Hurme S, Bueter M, Helmiö M, Juuti A, Meyer-Gerspach AC, Slawik M, Peromaa-Haavisto P, Nuutila P, Salminen P. Laparoscopic Roux-en-Y-Gastric Bypass versus Laparoscopic Sleeve Gastrectomy: 5-Year Outcomes of Merged Data of Two Randomized Clinical Trials (SLEEVEPASS and SM-BOSS). British Journal of Surgery. 2021 Jan. 108(1):49-57. DOI: 10.1093/bjs/znaa011
     
  • Wölnerhanssen B: Raffinierter Zucker – Wertvolle Energie oder physiologischer Unsinn? Karger, Quintessence Publishing. pp 480–487, 2020
     
  • °Nussbaumer R, °Meyer-Gerspach AC, Peterli R, Peters T, Beglinger C, Chiappetta S, Drewe J, Wölnerhanssen BK. First-Phase Insulin and Amylin after Bariatric Surgery: A Prospective Randomized Trial on Patients with Insulin Resistance or Diabetes after Gastric Bypass or Sleeve Gastrectomy. Obesity Facts. 2020 Dec. 13(6):584-595. DOI: 10.1159/000511928 °authors contributed equally to the manuscript
     
  • Farin W, Oñate FP, Plassais J, Bonny C, Beglinger C, Woelnerhanssen B, Nocca D, Magoules F, Le Chatelier E, Pons N, Cervino ACL, Ehrlich SD. Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis. Surg Obes Relat Dis. 2020 Jul.16(7):852-862. DOI: 10.1016/j.soard.2020.03.014
  • Farin W, Oñate FP, Plassais J, Bonny C, Beglinger C, Woelnerhanssen B, Nocca D, Magoules F, Le Chatelier E, Pons N, Cervino ACL, Ehrlich SD. Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis. Surg Obes Relat Dis. 2020 Jul;16(7):852-862. DOI. Epub 2020 Mar 20.
     
  • Wölnerhanssen BK, Meyer-Gerspach AC; Health effects of sugar consumption and possible alternatives. Ther Umsch. 2019 Sep; 76(3): 111–116. DOI
     
  • Meyer-Gerspach AC, Peterli R, Moor M, Madörin P, Schötzau A, Nabers D, Borgwardt S, Beglinger C, Bieri O, Wölnerhanssen BK. Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery. Obes Surg. 2019 May 14. DOI
     
  • Streese L, Königstein K, Goricki L, Infanger D, Wölnerhanssen B, Peters T, Schmidt-Trucksäss A, Hanssen H; Short- and Long-Term Effects of Bariatric Surgery on Vascular Phenotype.  Obes Surg. 2019 Apr;29(4):1301-1308. DOI
     
  • Fox M, Meyer-Gerspach AC, Wendebourg MJ, Gruber M, Heinrich H, Sauter M, Wölnerhanssen B, Koeberle D, Juengling F. Effect of cocoa on the brain and gut in healthy subjects: a randomized controlled trial. Br J Nutr. 2019 Mar; 121(6): 654-661. DOI
     
  • Chiappetta S, Schaack HM, Wölnerhanssen B, Stier C, Squillante S, Weiner RA. The Impact of Obesity and Metabolic Surgery on Chronic Inflammation.  Obes Surg. 2018 Oct;28(10): 3028–3040. DOI
     
  • Meyer-Gerspach AC, Ly HG, Borgwardt S, Dupont P, Beglinger C, Van Oudenhove L, Wölnerhanssen BK. Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: A pilot study. Diabetes Obes Metab. 2018 Oct;20(10): 2330–2338. DOI
     
  • Schneider R, Lazaridis I, Kraljević M, Beglinger C, Wölnerhanssen B, Peterli R. The impact of preoperative investigations on the Management of bariatric patients; results of a cohort of more than 1200 cases. Surg Obes Relat Dis. 2018 May;14(5):693-699. DOI. Epub 2018 Jan 12
     
  • Shimobayashi M, Albert V, Wölnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jenö P, Beglinger C, Peterli R, Hall MN. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018 Apr 2; 128(4): 1538–1550. DOI
     
  • °Zanchi D, °Meyer-Gerspach AC, Schmidt A, Suenderhauf C, Depoorter A, Drewe J, Beglinger C, °Wölnerhanssen BK, °Borgwardt S. Acute effects of glucose and fructose administration on the neural correlates of cognitive functioning in healthy subjects: a pilot study. Front in Psychiatry. 2018 Mar 12; 9:71. Epub 2018 Mar. DOI ° authors contributed equally to the manuscript
     
  • Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M. Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial. JAMA. 2018 Jan 16; 319(3):255-265. DOI
     
  • °Wölnerhanssen BK, °Moran AW, °Burdyga G, °Meyer-Gerspach AC, Peterli R, Manz M, Thumshirn M, Daly K, Beglinger C, Shirazi-Beechey SP. Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals. Sci Rep. 2017 Aug 15; 7(1):8174. DOI ° authors contributed equally to the manuscript
     
  • Schneider R, Lazaridis I, Kraljević M, Beglinger C, Wölnerhanssen B, Peterli R / The impact of preoperative investigations on the management of bariatric patients; results of a cohort of more than 1200 cases. Surg Obes Relat Dis. 2018 May;14(5): 693-699. DOI . Epub 2018 Jan 12.
     
  • °Wilbaux M, °Wölnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Pfister M / Characterizing the dynamic interaction among gastric emptying, glucose absorption and glycemic control in non-diabetic obese adults. Am J Physiol Regul Integr Comp Physiol. 2017 Mar 1; 312(3): R314-R323. DOI ° authors contributed equally to the manuscript
     
  • Peterli R., Wölnerhanssen B., Vetter D., Nett P., Gass M., Borbely Y., Peters T., Schiesser M., Schultes B., Beglinger C., Drewe J., Bueter, M.: Laparoscopic Sleeve Gastrectomy versus Roux-Y-Gastric Bypass for Morbid Obesity – 3-Year-Outcomes of the prospective randomized Swiss Multicentre Bypass or Sleeve Study (SM-BOSS). Ann Surg. 2017 Mar;265(3):466-473. DOI
     
  • Meyer-Gerspach AC, Häfliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wölnerhanssen B. Effect of L-tryptophan and L-leucine on gut hormone secretion, appetite feelings and gastric emptying rates in lean and non-diabetic obese participants: a randomized, double-blind, parallel-group trial. PLoS One. 2016 Nov 11(11):e0166758. DOI
     
  • °Zanchi D, °Meyer-Gerspach AC, Suenderhauf C, Janach K, Le Roux CW, Haller S, Drewe J, Beglinger C, °Wölnerhanssen BK, °Borgwardt S. Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels. Sci Rep. 2016 Oct 20; 6:35727. DOI ° authors contributed equally to the manuscript
     
  • °Wölnerhanssen BK, °Meyer-Gerspach AC, Peters T, Beglinger C, Peterli R. Incretin effects, gastric emptying and insulin responses to low oral glucose loads in patients after gastric bypass and lean and obese controls. Surg Obes Relat Dis. 2016 Aug; 12(7):1320-1327. Epub 2015 Nov 27. DOI ° authors contributed equally to the manuscript
     
  • °Meyer-Gerspach AC, °Suenderhauf C, Bereiter L, Zanchi D, Beglinger C, Borgwardt S, Wölnerhanssen BK. Gut taste stimulants alter brain activity in areas related to working memory: a pilot study. Neurosignals. 27 Jul 2016: 24(1):59-70. DOI ° authors contributed equally to the manuscript
     
  • Wölnerhanssen BK, Cajacob L, Keller N, Doody A, Rehfeld JF, Peterli R, Beglinger C, Meyer-Gerspach AC. Gut hormone secretion, gastric emptying and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab. Jun 2016: 310(11):E1053-61. DOI
     
  • Schneider J., Peterli R., Gass M., Slawik M., Peters T., Wölnerhanssen B.: Laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass lead to equal changes in body composition and energy metabolism 17 months postoperatively: a prospective randomized trial. Surg Obes Relat Dis. Mar–Apr 2016: 12(3): 563–570. DOI Epub 2015 Jul 9.
     
  • Meyer-Gerspach AC, Cajacob L, Riva D, Herzog R, Drewe J, Beglinger C, Wölnerhanssen BK. Mechanisms regulating insulin response to intragastric glucose in lean and non-diabetic obese subjects: a randomized, double-blind, parallel-group trial. PLoS One. 4 Mar 2016: 11 (3):e0150803. DOI
     
  • Wölnerhanssen B, Peterli R.: Management of complications after bariatric surgery. Der Chirurg. 2015 Dec: 86(12):1114-20. DOI
     
  • °Wölnerhanssen BK, °Meyer-Gerspach AC, Schmidt A, Zimak N, Peterli R, Beglinger C, Borgwardt S. Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study. PLoS One. Jun 2015; 10(6):e0130280.  DOI °authors contributed equally to the manuscript
     
  • Schmidt A, Hammann F, Wölnerhanssen B, Meyer-Gerspach AC, Drewe J, Beglinger C, Borgwardt S.: Green tea extract enhances bottom-up effective connectivity during working memory processing. Psychopharmacology Oct;231(19):3879-88, 2014. DOI Epub 2014 Mar 19.
     
  • Meyer-Gerspach AC, Wölnerhanssen B, Beglinger B, Nessenius F, Napitupulu M, Schulte FH, Steinert RE, Beglinger C. Gastric and intestinal satiation in obese and normal weight healthy people. Physiology & Behavior. Apr 2014 129:265-71. DOI Epub 2014 Feb 28. 
     
  • Wölnerhanssen B, Peterli R. State of the Art: Sleeve gastrectomy. Digestive Surgery: Bariatric Surgery special Edition. Dig Surg. 2014;31(1):40-7. DOI. Epub 2014 May 8.
     
  • Meyer-Gerspach AC, Wölnerhanssen B, Beglinger C. Gut sweet taste receptors and their role in metabolism. Van der Lely A, Delhanty P (Eds). Front Horm Res. Basel, Karger, 2014, vol 42, pp 123-133. DOI
     
  • Peterli R, Steinert RE, Wölnerhanssen B, Peters T, Christoffel-Courtin C, Gass M, Kern B, von Fluee M, Beglinger C. Metabolic and Hormonal Changes After Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: a Randomized, Prospective Trial. Obes Surg. 22(5):740-8, 2012 May / DOI
     
  • Wölnerhanssen B, Peterli R, Borbély Y, Peters T, Christoffel-Courtin C, Kern B, von Flüe M, Beglinger C.: Effects of post-bariatric surgery weight loss on adipokines and metabolic parameters: Comparison of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) - a prospective randomized trial. Surg Obes Relat Dis. 2011 Sep-Oct;7(5): 561-8. DOI
     
  • Uglioni B, Wölnerhanssen B, Peters T, Christoffel-Courtin C, Kern B, Peterli R.: Mid-term results of primary vs secondary laparoscopic sleeve gastrectomy (LSG) as an isolated operation. Obesity Surgery.  Jan 2009: 19(4):401-6. DOI
     
  • Peterli R, Wölnerhanssen B, Devaux N, Kern B, Peters T, Christoffel C, Drewe J, Von Flüe M, Beglinger C.: Improvement in glucose metabolism after bariatric surgery: Comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective randomized trial. Ann Surg. 2009 Aug;250(2):234-41. DOI
     
  • Wölnerhanssen B, Langer I, Eriksson U, Schneider M.: Sudden death after Gastric Bypass: Case report. Langenbecks Arch Surg. 2009 May;394(3):573-7. DOI. Epub 2008 Jul 3
     
  • Wölnerhanssen B, Kern B, Peters T, von Flüe M, Peterli R.: Predictors of outcome after laparoscopic gastric banding in the treatment of morbid obesity. Surg Obes Relat Dis. Jul-Aug 2008; 4(4):500-6, DOI. Epub 2008 Jun 30.
     
  • Peterli R, Wölnerhanssen B, Kern B, Ackermann C, Von Flüe M, Peters T.: Prospective Study of a Two-Stage Operative Concept in the Treatment of Morbid Obesity: Primary Lap-Band® Followed if Needed by Sleeve Gastrectomy with Duodenal Switch. Obes Surg. 2007 Mar;17(3):334-40.  DOI
     
  • Wölnerhanssen B, Küng C, Wolff T, Gürke L, Eugster T.: Ruptured aneurysm of pancreatico-duoneal artery: Case report Chirurgia, 20:307-8, 2007
     
  • Wölnerhanssen B, Cajacob L, Keller N, Doody A, Rehfeld JF, Drewe J, Peterli R, Beglinger C, Meyer-Gerspach AC.: Gut hormone secretion, gastric emptying and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1053-61. Epub 2016 Apr 26. Wölnerhanssen B, Peterli R: Therapie der Leistenhernie. Springer Lexikon, 2005. DOI
     
  • Wölnerhanssen B, Kern B, Peters T, Ackermann C, von Flüe M, Peterli R.: Reduction in slippage-rate with 11cm Lap Band® and change of gastric banding technique. Obesity Surgery. 2005 Aug; 15(7):1050-4. DOI
     
  • Wölnerhanssen B, Ackermann C, Guenin Mo, Kern B, Tondelli P, von Flüe M, Peterli R. 12 Jahre laparoskopische Cholezystektomie: Resultate einer prospektiven Studie von 4498 an einer Klinik durchgeführten Cholezystektomien. Chirurg. Mar 2005; 76:263-9. DOI

Review articles

 

Book chapters

  • Meyer-Gerspach AC, Wölnerhanssen BK. Einflüsse der Ernährung auf den Speichel. Filippi A, Waltimo T (eds.): Speichel. Quintessence Publishing. pp 280-288, 2020.
     
  • Wölnerhanssen B, Beglinger C.: Therapeutic potential of gut peptides. Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 54–63
     
  • Wölnerhanssen B, Sjöström H, Herrle F.:  Handbuch für chirurgische Assistenten SCS/ Manual for Residents in Surgery, St. Claraspital, Basel, Edition: 2003, 2005
     
  • Wölnerhanssen B, Peterli R / Eingeweidebrüche/Hernien / Springer Lexikon / 2006
     
  • Wölnerhanssen B, Peterli R / Therapie der Leistenhernie / Springer Lexikon / 2005