Co-Head of the Metabolics/Gastroenterology Research Group

Anne Christin Meyer-Gerspach

Meyer Gerspach Anne Christin

Professional career

Curriculum vitae

Since 2019

Group leader "Obesity, Diabetes and Metabolism Research"/"Surgical and Gastroenterological Research" (Research Clarunis site St. Claraspital/St. Clara Forschung AG)

2019

Habilitation, Experimental Medicine, University of Basel, Switzerland

2018

Senior Scientist
St. Clara Research AG

2016-2018

Academic Research Associate in the field of metabolism
Clinical Research Department St. Claraspital Basel

2014-2016

Postdoctoral Research, Gastrointestinal Motility
Translational Research Centre for Gastrointestinal Disorders, Catholic University of Leuven, Belgium

2012-2014

Postdoctoral Research, Nutritional Physiology
Department of Biomedicine, Gastroenterology, University Hospital Basel, Switzerland

Pu­bli­ca­ti­ons

  • Teysseire F, Bordier V, Beglinger C, Wölnerhanssen BK, Meyer-Gerspach AC. Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review. Nutrients. 2024 Feb 23;16(5):622. DOI: 10.3390/nu16050622
  • Bordier V, Teysseire F, Drewe J, Madörin P, Bieri O, Schmidt-Trucksäss A, Hanssen H, Beglinger C, Meyer-Gerspach AC, Wölnerhanssen BK. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health. 2023 Nov 14;6(2):264-272. DOI: 10.1136/bmjnph-2023-000764
  • Wölnerhanssen BK, Meyer-Gerspach AC, Nussbaumer R, Sauter M, Thumshirn M, Bueter M, Vetter D, Gubler C, Morell B, Jell A, Vieth M, Beglinger C, Peterli R, Fox M. Prospective clinical cohort study: low incidence of Barrett's esophagus but high rate of reflux disease at 5-year follow-up after sleeve gastrectomy versus Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2023 Jul;19(7):707-715. DOI: 10.1016/j.soard.2023.02.012
  • Shimobayashi M, Thomas A, Shetty S, Frei IC, Wölnerhanssen BK, Weissenberger D, Vandekeere A, Planque M, Dietz N, Ritz D, Meyer-Gerspach AC, Maier T, Hay N, Peterli R, Fendt SM, Rohner N, Hall MN. Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia. Elife. 2023 Mar 15;12:e85103. DOI: 10.7554/eLife.85103
  • Wölnerhanssen BK, Meyer-Gerspach AC, Nussbaumer R, Sauter M, Thumshirn M, Bueter M, Vetter D, Gubler C, Morell B, Jell A, Vieth M, Beglinger C, Peterli R, Fox M. Prospective clinical cohort study: low incidence of Barrett's esophagus but high rate of reflux disease at 5-year follow-up after sleeve gastrectomy versus Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2023 Feb 27:S1550-7289(23)00082-5. DOI: 10.1016/j.soard.2023.02.012. Epub ahead of print.
  • Teysseire F, Bordier V, Budzinska A, Van Oudenhove L, Weltens N, Beglinger C, Wölnerhanssen BK, Meyer-Gerspach AC. Metabolic Effects and Safety Aspects of Acute D-allulose and Erythritol Administration in Healthy Subjects. Nutrients. 2023 Jan 15;15(2):458. DOI: 10.3390/nu15020458
  • Teysseire F, Flad E, Bordier V, Budzinska A, Weltens N, Rehfeld JF, Beglinger C, Van Oudenhove L, Wölnerhanssen BK, Meyer-Gerspach AC. Oral Erythritol Reduces Energy Intake during a Subsequent ad libitum Test Meal: A Randomised, Controlled, Crossover Trial in Healthy Humans. Nutrients. 2022 Sep 21;14(19):3918. DOI: 10.3390/nu14193918
  • Bordier V, Teysseire F, Senner F, Schlotterbeck G, Drewe J, Beglinger C, Wölnerhanssen BK, Meyer-Gerspach AC. Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study. Int J Mol Sci. 2022 Aug 30;23(17):9867. DOI: 10.3390/ijms23179867
  • Teysseire F, Bordier V, Budzinska A, Weltens N, Rehfeld JF, Holst JJ, Hartmann B, Beglinger C, Van Oudenhove L, Wölnerhanssen BK, Meyer-Gerspach AC. The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial. J Nutr. 2022 May 5;152(5):1228-1238. DOI: 10.1093/jn/nxac026
  • Bordier V, Teysseire F, Schlotterbeck G, Senner F, Beglinger C, Meyer-Gerspach AC, Wölnerhanssen BK. Effect of a Chronic Intake of the Natural Sweeteners Xylitol and Erythritol on Glucose Absorption in Humans with Obesity. Nutrients. 2021 Nov 5;13(11):3950.
  • Anne Christin Meyer-Gerspach, Jed O. Wingrove, Christoph Beglinger, Jens F. Rehfeld, Carel W. Le Roux, Ralph Peterli, Patrick Dupont, Owen O'Daly, Lukas Van Oudenhove & Bettina K. Wölnerhanssen (2021): Erythritol and xylitol differentially impact brain networks involved in appetite regulation in healthy volunteers, Nutritional Neuroscience. 2021 Aug. DOI: 10.1080/1028415X.2021.1965787
  • Bühler J, Rast S, Beglinger C, Peterli R, Peters T, Gebhart M, °Meyer-Gerspach AC, °Wölnerhanssen BK. Long-Term Effects of Laparoscopic Sleeve Gastrectomy and Roux-Y-Gastric Bypass on Body Composition and Bone Mass Density. Obesity Facts. 2021 Mar. 14(1):131-140. DOI: 10.1159/000512450 °authors contributed equally to the manuscript
  • Wölnerhanssen BK, Drewe J, Verbeure W, le Roux CW, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Meyer-Gerspach AC. Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study. Diabetes Obes Metab. 2021 Feb. DOI: 10.1111/dom.14342
  • Bühler J, Rast S, Beglinger C, Peterli R, Peters T, Gebhart M, °Meyer-GerspachAC, °Wölnerhanssen BK. Long-Term Effects of Laparoscopic Sleeve Gastrectomy and Roux-Y-Gastric Bypass on Body Composition and Bone Mass Density. Obesity Facts. 2021 Mar. 14(1):131-140. DOI: 10.1159/000512450 °authors contributed equally to the manuscript
  • Meyer-Gerspach AC, Drewe J, Verbeure W, Roux CWL, Dellatorre-Teixeira L, Rehfeld JF, Holst JJ, Hartmann B, Tack J, Peterli R, Beglinger C, Wölnerhanssen BK. Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study. Nutrients. 2021 Jan. 8;13(1):174. https://doi. org/10.3390/nu13010174
  • Wölnerhanssen BK, Peterli R, Hurme S, Bueter M, Helmiö M, Juuti A, Meyer-Gerspach AC, Slawik M, Peromaa-Haavisto P, Nuutila P, Salminen P. Laparoscopic Roux-en-Y-Gastric Bypass versus Laparoscopic Sleeve Gastrectomy: 5-Year Outcomes of Merged Data of Two Randomised Clinical Trials (SLEEVEPASS and SM-BOSS). British Journal of Surgery. 2021 Jan. 108(1):49-57. DOI: 10.1093/bjs/znaa011
  • Nussbaumer R, Meyer-GerspachAC, Peterli R, Peters T, Beglinger C, Chiappetta S, Drewe J, Wölnerhanssen BK. First-Phase Insulin and Amylin after Bariatric Surgery: A Prospective Randomised Trial on Patients with Insulin Resistance or Diabetes after Gastric Bypass or Sleeve Gastrectomy. Obesity Facts. 2020 Dec. 13(6):584-595. DOI: 10.1159/000511928 °authors contributed equally to the manuscript
  • Wölnerhanssen BK, Meyer-Gerspach AC; Health effects of sugar consumption and possible alternatives. Ther Umsch. 2019 Sep; 76(3): 111-116.
  • Meyer-Gerspach AC, Peterli R, Moor M, Madörin P, Schötzau A, Nabers D, Borgwardt S, Beglinger C, Bieri O, Wölnerhanssen BK. Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery. Obes Surg. 2019 May 14.
  • Fox M, Meyer-Gerspach AC, Wendebourg MJ, Gruber M, Heinrich H, Sauter M, Wölnerhanssen B, Koeberle D, Juengling F; Effect of cocoa on the brain and gut in healthy subjects: a randomised controlled trial. Br J Nutr. 2019 Mar: 121(6): 654-661.
  • Meyer-Gerspach AC, Wölnerhanssen BK. The adverse effects of sugar consumption - why we need to reduce it. LymphForsch. 2018; 22(2): 70-75.
  • Meyer-Gerspach AC, Ly HG, Borgwardt S, Dupont P, Beglinger C, Van Oudenhove L, Wölnerhanssen BK. Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: A pilot study. Diabetes Obes Metab. 2018 Oct;20(10): 2330-2338.
  • Meyer-Gerspach AC, Biesiekierski JR, Deloose E, Clevers E, Rotondo A, Rehfeld JF, Depoortere I, Van Oudenhove L, Tack J. Effects of caloric and noncaloric sweeteners on antroduodenal motility, gastrointestinal hormone secretion and appetite-related sensations in healthy subjects. Am J Clin Nutr. 2018 May 1; 107(5): 707-716
  • Shimobayashi M, Albert V, Wölnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, Clement N, Moes S, Colombi M, Meier JA, Swierczynska MM, Jenö P, Beglinger C, Peterli R, Hall MN.Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018 Apr 2; 128(4): 1538-1550.
  • °Zanchi D, °Meyer-Gerspach AC, Schmidt A, Suenderhauf C, Depoorter A, Drewe J, Beglinger C, °Wölnerhanssen BK, °Borgwardt S. Acute effects of glucose and fructose administration on the neural correlates of cognitive functioning in healthy subjects: a pilot study. Front in Psychiatry. 2018 Mar 12; 9:71. Epub 2018 Mar. DOI ° authors contributed equally to the manuscript
  • °Zhao D, °Meyer-Gerspach AC, Deloose E, Iven J, Weltens N, Depoortere I, O'daly O, Tack J, Van Oudenhove L. The motilin agonist erythromycin increases hunger by modulating homeostatic and hedonic brain circuits in healthy women: a randomised, placebo-controlled study. Sci Rep. 2018 Jan 29 8(1):1819. DOI ° authors contributed equally to the manuscript
  • °Wölnerhanssen BK, °Moran AW, °Burdyga G, °Meyer-Gerspach AC, Peterli R, Manz M, Thumshirn M, Daly K, Beglinger C, Shirazi-Beechey SP / Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals / Sci Rep. 2017 Aug 15; 7(1):8174. DOI ° authors contributed equally to the manuscript
  • Wilbaux M, Wölnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Pfister M. Characterising the dynamic interaction among gastric emptying, glucose absorption and glycemic control in non-diabetic obese adults. Am J Physiol Regul Integr Comp Physiol. Epub 2016 Dec 14.
  • Meyer-Gerspach AC, Häfliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wölnerhanssen B. Effect of L-tryptophan and L-leucine on gut hormone secretion, appetite feelings and gastric emptying rates in lean and non-diabetic obese participants: a randomised, double-blind, parallel-group trial. PLoS One. Epub 2016 Nov 22.
  • Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, Le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S. Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels. Sci Rep Epub 2016 Oct 20.
  • Meyer-Gerspach AC, Suenderhauf C, Bereiter L, Zanchi D, Beglinger C, Borgwardt S, Wölnerhanssen BK. Gut taste stimulants alter brain activity in areas related to working memory: a pilot study. Neurosignals. 2016;24(1):59-70. doi: 10.1159/000442612. Epub 2016 Jul 27.
  • Wölnerhanssen BK, Cajacob L, Keller N, Doody A, Rehfeld JF, Peterli R, Beglinger C, Meyer-Gerspach AC. Gut hormone secretion, gastric emptying and glycemic responses to erythritol and xylitol in lean and obese subjects. Am J Physiol Endocrinol Metab. 2016. Epub 2016 Apr 26.
  • Meyer-Gerspach AC, Cajacob L, Riva D, Herzog R, Drewe J, Beglinger C, Wölnerhanssen BK. Mechanisms regulating insulin response to intragastric glucose in lean and non-diabetic obese subjects: a randomised, double-blind, parallel-group trial. PLoS One. 2016 Mar4; 11(3):e0150803. DOI
  • Wölnerhanssen BK, Meyer-Gerspach AC, Peters T, Beglinger C, Peterli R. Incretin effects, gastric emptying and insulin responses to low oral glucose loads in patients after gastric bypass and lean and obese controls. Surg Obes Relat Dis. 2016 Aug;12(7):1320-1327. DOI. Epub 2015 Nov 27.
  • Wölnerhanssen BK, Meyer-Gerspach AC, Schmidt A, Zimak N, Peterli R, Beglinger C, Borgwardt S. Dissociable Behavioural, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study. PLoS One. Jun 2015; 10(6):e0130280. DOI °authors contributed equally to the manuscript
  • Schmidt A, Hammann F, Wölnerhanssen B, Gerspach A, Drewe J, Beglinger C, Borgwardt S.: Green tea extract enhances bottom-up effective connectivity during working memory processing. Psychopharmacology Oct;231(19):3879-88, 2014. DOI Epub 2014 Mar 19.
  • Steinert RE, Schirra J, Meyer-Gerspach AC, Kienle P, Fischer H, Schulte FH, Goeke B, Beglinger C. Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men. Am J Clin Nutr. Aug 2014 100(2):514-23. DOI
  • Beglinger S, Meyer-Gerspach AC, Graf S, Zumsteg U, Drewe J, Beglinger C, Gutzwiller JP. Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents. Obesity. Sep 2014 22(9):2047-52. DOI ° authors contributed equally to the manuscript
  • Meyer-Gerspach AC, Wölnerhanssen B, Beglinger B, Nessenius F, Schulze FH, Steinert RE, Beglinger C. Gastric and intestinal satiation in obese and normal weight healthy people. Physiology & Behaviour. Apr 2014 129:265-71. DOI Epub 2014 Feb 28.
  • Bernsmeier C, Meyer-Gerspach AC, Blaser L, Jeker L, Steinert RE, Heim MH, Beglinger C. Glucose-induced glucagon-like peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease. PLoS One. 2014 Jan 9(1):e87488. DOI Epub 2014 Jan 29.
  • Steinert RE, Peterli R, Keller S, Meyer-Gerspach AC, Drewe J, Peters T, Beglinger C.Bile acids and gut peptide secretion after bariatric surgery - a 1 year prospective randomised pilot trial. Obesity. 2013 Dec 21(12):E660-8. DOI Epub 2013 Jun 26.
  • Meyer-Gerspach AC, Steinert RE, Keller S, Malarski A, Schulte FH, Beglinger C. Effects of chenodeoxycholic acid on the secretion of gut peptides and fibroblast growth factors in healthy humans. J Clin Endocrinol Metab. 2013 Aug 98(8):3351-8. DOI Epub 2013 Jun 19.
  • Steinert RE, Meyer-Gerspach AC, Beglinger C. The role of the stomach in the control of appetite and the secretion of satiation peptides / Am J Physiol Endocrinol Metab / 302(6):E666-73 / 2012 Mar / DOI ° authors contributed equally to the manuscript. Epub 2012 Jan 3.
  • Gerspach AC, Steinert RE, Schönenberger L., Graber-Maier A., Beglinger C. The role of the gut sweet taste receptor in regulating GLP-1 and PYY release in humans. Am J Physiol Endocrinol Metab. 2011 Aug;301(2):E317-25. epub 2011 May 3.
  • Steinert RE, Gerspach AC, Gutmann H, Asarian L, Drewe J, Beglinger C. The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Clin Nutr. 2011 Aug;30(4):524-32. Epub 2011 Feb 15.


      • Review articles

      • Inta D, Wölnerhanssen BK, Meyer-Gerspach AC, Lang E, Schweinfurth N, Mallien AS, Vasilescu AN, Schmidt A, Rea K, Westendorf AM, Tremblay ME, Sartorius A, Gass P, Cryan JF, Borgwardt S, Lang UE. Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets. Curr Behav Neurosci Rep. 2020 Jan 7;15-21. https://doi. org/10.1007/s40473-020-00199-1
      • Wölnerhanssen BK, Meyer-Gerspach AC. Letter Regarding Article, "Metabolomic Pattern Predicts Incident Coronary Heart Disease". Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):e186. DOI
      • Wölnerhanssen BK, Meyer-Gerspach AC, Beglinger C, Islam MS. Metabolic effects of the natural sweeteners xylitol and erythritol: A comprehensive review. Crit Rev Food Sci Nutr. 2019 Jun 16:1-13. DOI
      • Meyer-Gerspach AC, Wölnerhanssen BK. The adverse effects of sugar consumption - why we need to reduce it. LymphForsch. 2018; 22(2): 70-75.
      • Wölnerhanssen B, Meyer-Gerspach AC, Beglinger C. Reply to letter to the editor: the tolerance of erythritol and xylitol based on effective dose methodologies. Am J Physiol Endocrinol Metab. 2016. Epub 2016 Oct 01. IF: 4.61
      • Meyer-Gerspach AC, Wölnerhanssen B, Beglinger C. Functional roles of low calorie sweeteners on gut function. Physiology & Behaviour. Epub 2016 Feb 06. IF: 3.19

Me­dia

2024


2023